The San Francisco 49ers’ championship hopes may ride on when running back and reigning Offensive Player of the Year Christian McCaffrey returns.

An update has been given by San Francisco 49ers head coach Kyle Shanahan on Christian McCaffrey's status. The update is that there is no update. McCaffrey will

The San Francisco 49ers lost another running back on Thursday night, with fill-in starter Jordan Mason exiting Week 6's victory over the Seattle Seahawks with a shoulder injury. They'll have to make do,

All eyes will be on QBs Brock Purdy and Patrick Mahomes when the San Francisco 49ers (3-3) and Kansas City Chiefs (5-0) play on Oct. 20. Which signal-caller is better equipped to bring home a win in this matchup? We break it all down below.

At 2-3 overall and 0-2 in the NFC West division, a loss to the Seahawks wouldn't have buried the 49ers' season but it would have dug the hole plenty deep. Even as things piled up against San Francisco on Thursday night in Seattle -- more injuries,

Some of the dramatics in the San Francisco 49ers’ Week 6 win over the Seattle Seahawks could have been ratcheted down had the NFL’s replay review system operated properly. In the fourth quarter the Seahawks cut the 49ers’ 20-point lead to 6 with back-to-back touchdowns.

When Geno Smith stepped to the microphone after another gut-punch of a loss for the Seahawks, this one a 36-24 home defeat to division rival San Francisco, he wasn’t about make any excuses. “Obviously we did a lot of things that you don’t want to do when you talk about winning football games,

One big storyline from Thursday's Seahawks loss was a 49ers challenge that appeared to have been ruled incorrectly because the NFL wasn't provided the best video by Amazon.